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Patrick J Bednarski Selected Research

ezogabine (retigabine)

3/2022Modifications of the Triaminoaryl Metabophore of Flupirtine and Retigabine Aimed at Avoiding Quinone Diimine Formation.
1/2022Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation.
1/2019Flupirtine and retigabine as templates for ligand-based drug design of KV7.2/3 activators.
2/2015Oxidation potentials of N-modified derivatives of the analgesic flupirtine linked to potassium KV 7 channel opening activity but not hepatocyte toxicity.

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Patrick J Bednarski Research Topics

Disease

40Neoplasms (Cancer)
12/2021 - 05/2003
7Pain (Aches)
03/2022 - 02/2015
5Small Cell Lung Carcinoma (Small Cell Lung Cancer)
08/2011 - 11/2007
4Epilepsy (Aura)
03/2022 - 02/2015
4Chemical and Drug Induced Liver Injury
03/2022 - 11/2018
4Carcinoma (Carcinomatosis)
12/2021 - 01/2017
4Pancreatic Neoplasms (Pancreatic Cancer)
06/2021 - 05/2003
3Phototoxic Dermatitis (Phototoxicity)
12/2021 - 05/2011
3Urinary Bladder Neoplasms (Bladder Cancer)
12/2020 - 01/2006
3Breast Neoplasms (Breast Cancer)
06/2008 - 12/2007
2Uterine Cervical Neoplasms (Cancer of the Cervix)
12/2020 - 01/2018
2Lung Neoplasms (Lung Cancer)
10/2014 - 05/2003
2B-Cell Lymphoma (Lymphoma, B Cell)
11/2012 - 12/2007
1Ovarian Neoplasms (Ovarian Cancer)
06/2021
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
06/2021
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
06/2021
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
06/2021
1Seizures (Absence Seizure)
01/2019
1Head and Neck Neoplasms (Head and Neck Cancer)
10/2018
1Burkitt Lymphoma (Burkitt's Lymphoma)
01/2018
1Myalgia
03/2015
1Multiple Myeloma
01/2014
1Decompression Sickness (Bends)
08/2012

Drug/Important Bio-Agent (IBA)

14Cisplatin (Platino)FDA LinkGeneric
10/2018 - 09/2003
7flupirtineIBA
03/2022 - 02/2015
7PlatinumIBA
01/2018 - 12/2004
7LigandsIBA
10/2014 - 04/2009
6Glutathione (Reduced Glutathione)IBA
12/2020 - 09/2003
5EnzymesIBA
12/2021 - 05/2003
5Antineoplastic Agents (Antineoplastics)IBA
12/2021 - 12/2004
4Pharmaceutical PreparationsIBA
03/2022 - 02/2008
4ezogabine (retigabine)IBA
03/2022 - 02/2015
41-phenyl-3,3-dimethyltriazene (PDT)IBA
12/2021 - 01/2016
4Gentian Violet (Violet, Crystal)FDA Link
06/2021 - 03/2009
4DNA (Deoxyribonucleic Acid)IBA
01/2018 - 09/2003
41,2-cyclohexanediamine (dach)IBA
08/2009 - 12/2004
3Proteins (Proteins, Gene)FDA Link
12/2021 - 04/2007
3temoporfinIBA
12/2021 - 10/2018
3Glutathione Peroxidase GPX1IBA
12/2021 - 01/2020
3Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA
01/2019 - 02/2015
3Carboplatin (JM8)FDA LinkGeneric
10/2018 - 12/2004
3Oxaliplatin (Eloxatin)FDA LinkGeneric
10/2018 - 12/2004
3Cytostatic AgentsIBA
01/2018 - 10/2014
2Potassium Channels (Potassium Channel)IBA
03/2022 - 01/2022
2Methanol (Carbinol)IBA
06/2021 - 03/2009
2PeroxidasesIBA
12/2020 - 03/2014
2Opioid Analgesics (Opioids)IBA
01/2019 - 11/2018
2Analgesics (Analgesic Drugs)IBA
01/2019 - 03/2015
2Glutathione PeroxidaseIBA
11/2012 - 04/2007
2Etoposide (VP 16)FDA LinkGeneric
11/2012 - 01/2006
2Methotrexate (Mexate)FDA LinkGeneric
11/2012 - 01/2006
2Methyl EthersIBA
01/2009 - 11/2007
22-phenylindoleIBA
06/2008 - 12/2007
2Member 1 Subfamily B ATP Binding Cassette TransporterIBA
12/2007 - 04/2007
2ATP-Binding Cassette Transporters (ABC Transporters)IBA
12/2007 - 04/2007
2Glutathione Reductase (Glutathione-Disulfide Reductase)IBA
04/2007 - 09/2003
1Histone Deacetylases (Histone Deacetylase)IBA
12/2021
1IsoenzymesIBA
12/2021
1Messenger RNA (mRNA)IBA
12/2021
1SirtuinsIBA
12/2021
1Sirtuin 1IBA
12/2021
1Histone Deacetylase InhibitorsIBA
12/2021
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
12/2021
1Reactive Oxygen Species (Oxygen Radicals)IBA
12/2021
1Biological ProductsIBA
07/2021
1BromidesIBA
06/2021
1benzamideIBA
12/2020
1SulfonamidesIBA
12/2020
1diphenyl (biphenyl)IBA
12/2020
1Therapeutic UsesIBA
01/2019
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
11/2018
1quinolineIBA
01/2018
1naphthaleneIBA
01/2018
11,2,4-triazoleIBA
01/2018
1QuinolinesIBA
01/2018
1benzotriazoleIBA
01/2018
1Urea (Carbamide)FDA LinkGeneric
01/2017
1Phenylthiourea (Phenylthiocarbamide)IBA
01/2017
1ThioureaIBA
01/2017
1Photosensitizing Agents (Photosensitizers)IBA
01/2016
1Oleic Acid (Oleate)IBA
01/2016
1AmidesIBA
01/2016
1CopperIBA
10/2014
1MisonidazoleIBA
03/2014
1sigma Receptors (sigma Receptor)IBA
01/2014
1ProdrugsIBA
07/2013
13-hydroxyflavoneIBA
12/2012
1Bortezomib (Velcade)FDA Link
11/2012
1hydroxide ionIBA
09/2012
1Cytotoxins (Cytolysins)IBA
09/2012
1MetalsIBA
08/2012
1NitrogenIBA
05/2011
1CarbonIBA
12/2010
1HexanesIBA
08/2009
1diamminedichlorodihydroxyplatinum IVIBA
08/2009
1EthersIBA
04/2009

Therapy/Procedure

4Therapeutics
01/2022 - 12/2007
3Photochemotherapy (Photodynamic Therapy)
12/2021 - 10/2018
3Drug Therapy (Chemotherapy)
03/2014 - 12/2007
1Radiotherapy
03/2014